Skill-Based Electronic Gaming Machines: Features that Mimic Video Gaming, Features that could Contribute to Harm, and Their Potential Attraction to Different Groups.

New gambling products have been developed over time as technology permits. For example, early mechanical slot machines were later replaced by electronic gaming machines (EGMs), which enabled a faster speed of play and more immersive experience. EGMs have in the decades since their invention become one of the main drivers of gambling expenditure worldwide and are one of the gambling products most strongly associated with harm. This literature review considers research relevant to a new subcategory of EGM, 'skill-based' EGMs, termed 'SGMs' here. SGMs can be highly varied in content, with some representing a minimal departure from EGMs, where the typical bonus round is replaced by some skill-based activity, such as a simple video game, which could increase the machine's appeal. Other SGMs feature more radical departures from conventional EGMs, such as multiplayer games using intellectual property from popular TV shows or video games. These skill-based elements could tap into common gambling fallacies such as the illusion of control, and therefore facilitate harmful engagement. SGMs could also be less harmful than current EGMs, if skill-based elements break the dissociative states associated with EGM gambling. The intellectual property used in SGMs may increase their appeal among people who generally do not gamble, and the skill-based elements could increase their interest among gamblers who predominately prefer skill-based gambling formats such as sports betting. The novelty and varied content of SGMs present many open questions, which research should aim to address in future.

Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design.

Subcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published literature that contribute to pain/discomfort upon SC injection from three perspectives: (1) device and delivery factors that cause physical pain, (2) formulation factors that trigger pain responses, and (3) human factors impacting pain perception. Leveraging the Consortium's collective expertise, we provide an assessment of the comparative and interdependent factors likely to impact SC injection pain. In addition, we offer expert insights and future perspectives to fill identified gaps in knowledge to help advance the development of patient-centric and well tolerated high-dose/high-volume SC drug delivery solutions.

Survey data on customer two-stage decision-making process in household vacuum cleaner market.

This paper presents the data collection method and introduces the dataset about consumers' consider-then-choose behaviors in the household vacuum cleaner market. First, we designed a questionnaire that collected participants' consideration and choice data, social network data, demographic information, and preferences for product features. In addition, we obtained data on vacuum cleaner product features through web scraping from online shopping websites. After data cleaning and processing, the resulting dataset enables investigation into customer preferences in two stages, namely the consideration and choice stages and the impact of social influence on the two-stage decision-making process. This dataset is unique as it is the first of its kind to collect both customers' revealed preferences in a two-stage decision-making process and their ego social networks. This enables the modeling of customer preferences while accounting for social influence. The published survey questionnaire can be used as a template to collect data on other products in support of customer preferences modeling and the design for market systems.

Research on product design of FAHP bone marrow aspiration needle.

Bone marrow aspiration is a crucial medical procedure to obtain bone marrow samples for diagnosis and treatment. However, traditional bone marrow aspiration needles face several challenges such as operational difficulties, inadequate sample acquisition, and patient discomfort. To address these issues, we aimed to design a bone marrow aspiration needle product by using fuzzy analytic hierarchical process (FAHP). The FAHP method was used to identify key factors in the design of the bone marrow aspiration needle, including technicality, usage, and application characteristics. The importance weights and priorities of each factor were determined through questionnaires and interviews with experts. A new bone marrow aspiration needle product was developed based on the results of the FAHP. The new product design considers the weights and priorities assigned to key factors, resulting in improved convenience during operation and a higher success rate of sample acquisition. This was achieved by optimising the structure and material selection of the needle. This study presents a novel bone marrow puncture needle product that effectively integrates the importance and priority of the key factors. It successfully enhances operational performance and patient experience, thereby offering an innovative solution to improve the success rate and therapeutic effect of bone marrow punctures.

Investigating the trends and causes of changes in human anthropometric dimensions over the past three decades: a challenge for ergonomic design.

Objectives. The present study aimed to review the changes in anthropometric dimensions around the world during the last 30 years.Methods. The search for this study was conducted in four databases with related keywords. Papers from 1990 to 2021 were reviewed and 4139 articles were identified, with 505 related titles. Of these, 187 articles met the eligibility criteria, and their whole text was examined; 132 articles were then included for the final review.Results. The reviewed studies showed that a large number of anthropometric dimensions of the human body have become larger than in the past, such as height. Although the increasing trend of anthropometric dimensions in the past has been faster than in recent years, decreasing changes have also been seen in some anthropometric dimensions, such as the human jaw, face width and head width. It should be noted that the main reasons for the changes mentioned in the studies are economics and family income, social conditions, health and nutrition.Conclusion. Since the process of changes in anthropometric dimensions is not always the same, anthropometric data should be updated regularly, and work environments and equipment should be reviewed or redesigned according to the new anthropometric data.

A dataset on anthropometric measurements of children in Jordan for ergonomic product design.

The assessment and examination of anthropometric measures in children are of paramount significance in the advancement and creation of furniture, tools, and toys that specifically addresses the requirements of children as users. The dataset analyzed a total of 354 children from Jordan, divided into six distinct age groups ranging from 6 months to 9 years. The linear static measures included the skeletal dimensions pertaining to the distances between joints in the body, as well as the dimensions of the middle and lower bodies. It consists of 23 anthropometric measurements such as: stature, sitting height, knee height, eye height sitting, chest depth and shoulder breadth and others. The dataset supports the article "Preliminary and Comprehensive Static Anthropometric Measurements of Jordanian Children for Various Age Groups" [1]. The available data may initiate the establishment of a connection between anthropometric measurements and other design attributes used in Jordanian society. Additionally, these data have the potential to provide valuable insights for the development of diverse functional products, including clothing and safety equipment specifically tailored for the needs of children in Jordan.

Defective Assistive Device Involvement in Older Adult Emergency Department Visits.

Background and Objectives: Many older adults adopt equipment to address physical limitations and reduce dependence on others to complete basic activities of daily living. Although a few prior studies have considered injuries associated with assistive devices for older adults, those studies focused on older adults' health and functional risks for injury. There is limited analysis of older adult injuries involving defective or malfunctioning assistive devices. Research Design and Methods: Data from this study are from the National Electronic Surveillance System All Injury Program which collected data on consumer product-related injuries from a probability sample of 66 hospital Emergency Departments across the United States. Data from 30 776 older adult Emergency Department (ED) injury narratives from 2016 to 2020 were coded according to the assistive device involved and whether malfunctioning led to the injury. The study team manually examined all narratives in which the assistive device was coded to have malfunctioned. Results: A total of 10 974 older adult ED cases were treated for 12 488 injuries involving a defective device. Injuries included 4 212 head and neck injuries (eg, concussion), 4 317 trunk injuries (eg, hip fractures), and 3 959 arm or leg injuries (eg, leg fracture). Of these patients, 4 586 were admitted to a hospital ward for further evaluation and treatment. Seventy percent of these patients were injured while using a walker; in contrast, wheelchairs were implicated in only 4% of the above cases. Design flaws were identified in 8 158 cases and part breakage/decoupling incidents in 2 816 cases. Discussion and Implications: Our findings provide evidence that assistive devices are actively involved in older adult injuries. Further research is needed to reduce injuries associated with assistive devices by educating patients and their careproviders about device use and assembly and developing effective methods for informing manufacturers about malfunctioning devices.

Exploring the potential of bacterial cellulose paste as a fat replacer for low-fat plant-based hamburger patties.

Plant-based hamburger patties (PHPs) with reduced fat content made using fat replacers will meet the consumption goals of individuals who consume meat alternative products for health. In this study, we developed a dual-alternative food model by analysing the applicability of bacterial cellulose paste (BCP) as a fat replacer and supplementing it in PHPs. BCPs were prepared with solid contents of (w/w; 1.0%, 1.5%, 2.0%, 2.5%, and 3.0%) and compared and analyzed with three types of conventional vegetable [coconut oil, margarine, and shortening (SH)] and animal fats (beef tallow, butter, and lard) for various characteristics (appearance, dimensional stability, hardness level, and rheological properties). According to the results, BCP with a solid content of 3.0% (w/w) had the most similar characteristics to SH. Therefore, using SH as a control fat, PHPs in which 0%, 25%, 50%, 75%, and 100% (w/w) SH were replaced by 3.0% (w/w) BCP were prepared. Analysis of the appearance, instrumental color, diameter reduction, thickness, cooking loss, and texture profile of the PHPs, confirmed that replacement of 25%-50% (w/w) SH with 3.0% (w/w) BCP in the preparation of PHP resulted in i) redder color, ii) better dimensional stability, iii) lower cooking loss, and iv) higher chewiness of the final products. The results of the sensory evaluation showed that the PHPs, with 25%-50% (w/w) SH replaced with 3.0% (w/w) BCP, exhibited no significant differences (p < 0.05) in overall preference scores compared to the full-SH sample. In conclusion, this study demonstrated the potential of BCP as a fat substitute for the production of PHPs.

Influence of 3D Printing Direction in PLA Acoustic Guitars on Vibration Response.

The design of musical instruments is a discipline that is still carried out in an artisanal way, with limitations and high costs. With the additive manufacturing technique, it is possible to obtain results for the generation of not only electrical but also acoustic instruments. However, it is necessary to generate a procedure to evaluate the influence of the process on the final result of the acoustics obtained. This study focuses on investigating the relationship between the construction of acoustic guitars and their final sound. The reinforcement structures at the top of the instrument are analysed, as well as how this design affects the vibratory behaviour of the top in the first five vibratory modes. Specifically, this article presents a procedure for the design of customised acoustic guitars using additive manufacturing through parametrisation and a vibrational analysis of the designed tops using finite element (FEA) and experimental physical tests, in order to develop a methodology for the study of stringed instruments. As a result, an 11% increase in the high-frequency response was achieved with a printing direction of +45°, and a reduction in the high-frequency response with ±45°. In addition, at high frequencies, a relative error of 5% was achieved with respect to the simulation. This work fulfils an identified need to study the manufacture of acoustic guitars using polylactic acid (PLA), and to be able to offer the musician a customised instrument. This represents a breakthrough in the use of this manufacturing technology, extending its relationship with product design.

Non-Invasive Glucose Sensing Technologies and Products: A Comprehensive Review for Researchers and Clinicians.

Diabetes Mellitus incidence and its negative outcomes have dramatically increased worldwide and are expected to further increase in the future due to a combination of environmental and social factors. Several methods of measuring glucose concentration in various body compartments have been described in the literature over the years. Continuous advances in technology open the road to novel measuring methods and innovative measurement sites. The aim of this comprehensive review is to report all the methods and products for non-invasive glucose measurement described in the literature over the past five years that have been tested on both human subjects/samples and tissue models. A literature review was performed in the MDPI database, with 243 articles reviewed and 124 included in a narrative summary. Different comparisons of techniques focused on the mechanism of action, measurement site, and machine learning application, outlining the main advantages and disadvantages described/expected so far. This review represents a comprehensive guide for clinicians and industrial designers to sum the most recent results in non-invasive glucose sensing techniques' research and production to aid the progress in this promising field.

T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information.

This work presents a granule size prediction approach applicable to diverse formulations containing new active pharmaceutical ingredients (APIs) in continuous twin-screw wet granulation. The approach consists of a surrogate selection method to identify similar materials with new APIs and a T-shaped partial least squares (T-PLS) model for granule size prediction across varying formulations and process conditions. We devised a surrogate material selection method, employing a combination of linear pre-processing and nonlinear classification algorithms, which effectively identified suitable surrogates for new materials. Using only material properties obtained through four characterization methods, our approach demonstrated its predictive prowess. The selected surrogate methods were seamlessly integrated with our developed T-PLS model, which was meticulously validated for high-dose formulations involving three new APIs. When surrogating new APIs based on Gaussian process classification, we achieved the lowest prediction errors, signifying the method's robustness. The predicted d-values were within the range of uncertainty bounds for all cases, except for d90 of API C. Notably, the approach offers a direct and efficient solution for early-phase formulation and process development, considerably reducing the need for extensive experimental work. By relying on just four material characterization methods, it streamlines the research process while maintaining a high degree of accuracy.

Toughening Brittle Bio-P3HB with Synthetic P3HB of Engineered Stereomicrostructures.

Poly(3-hydroxybutyrate) (P3HB), a biologically produced, biodegradable natural polyester, exhibits excellent thermal and barrier properties but suffers from mechanical brittleness, largely limiting its applications. Here we report a mono-material product design strategy to toughen stereoperfect, brittle bio or synthetic P3HB by blending it with stereomicrostructurally engineered P3HB. Through tacticity ([mm] from 0 to 100 %) and molecular weight (Mn to 788 kDa) tuning, high-performance synthetic P3HB materials with tensile strength to ≈30 MPa, fracture strain to ≈800 %, and toughness to 126 MJ m-3 (>110× tougher than bio-P3HB) have been produced. Physical blending of the brittle P3HB with such P3HB in 10 to 90 wt % dramatically enhances its ductility from ≈5 % to 95-450 % and optical clarity from 19 % to 85 % visible light transmittance while maintaining desirably high elastic modulus (>1 GPa), tensile strength (>35 MPa), and melting temperature (160-170 °C). This P3HB-toughening-P3HB methodology departs from the traditional approach of incorporating chemically distinct components to toughen P3HB, which hinders chemical or mechanical recycling, highlighting the potential of the mono-material product design solely based on biodegradable P3HB to deliver P3HB materials with diverse performance properties.

Intellectual Property and Royalty Payments Among Foot and Ankle Surgery Fellowship Faculty.

Faculty of the American College of Foot and Ankle Surgeons and American Orthopedic Foot and Ankle Society fellowship programs are uniquely positioned to provide advanced clinical and surgical training to fellows. One aspect of this training may include product design and mentorship through the associated intellectual property (IP) and patent timeline. This study describes the payments received and IP held among foot and ankle surgery fellowship faculty. A review of foot and ankle surgeons with royalties or license payments disclosed on the CMS Open Payments Database from 2014 to 2020 was conducted. Members with payments were then cross-referenced with the US Patent Full-Text Database to identify patents held. Fellowship affiliation, practice location, patent office, number of patents, citations, patent h-index, type of patent, and yearly payment values were recorded. Among the 2801 surgeons, 53 fellowship affiliates and 46 nonaffiliates maintained at least 1 patent and royalty/license payment. A total of 576 patents and 19,191 citations were assessed. The median number of patents and citations held by fellowship faculty was 3 and 60, respectively, while the median total payment value reached $165,197.09. Fixation devices comprised most of the patents and citations. Payment value positively correlated with number of patents held (p = .01), citations (p = .007), and patent h-index (p = .01) among fellowship-affiliated surgeons. Foot and ankle surgery fellowship faculty payments for IP are associated with the number and citability of patents held. While a small proportion of faculty were paid for intellectual property, the number of patents held and citations was comparable to other specialties.

Research on design elements of household medical products for rhinitis based on AHP.

To improve the scientificity of household medical product design for rhinitis patients, this study used the analytic hierarchy process (AHP) to provide guidance for household medical product design strategy. In the process of design decision-making, the identification of user needs and the evaluation of the scheme depend heavily on the designer's experience and knowledge. The main contribution of this paper is to evaluate the design elements through the AHP method and apply it to the actual design work. This work can greatly reduce the risk in design decisions. First, the AHP model and evaluation matrix of design elements were established and sorted out by semantic analysis of users' research results. Second, an expert group was invited to score using the 1-9 scale method. Then, the geometric mean method was used to calculate the weight shares of different indicators so as to rank them. Finally, the strategy was proposed based on ranking indicator weights, and product design was carried out. The application of AHP can make the product design process more objective and rigorous. The design scheme of this study can provide references and ideas to promote the vigorous development of household medical products for rhinitis patients.

Patient-centric drug product development: Acceptability across patient populations - Science and evidence.

The 6th APV (Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnologie e.V., The International Association for Pharmaceutical Technology) Winter Conference took place in Salzburg (Austria) from January 19-20, 2023. This conference was dedicated to advance patient-centric drug development across all dosage forms, indications and patient populations and was organized by the APV PaCeMe IN Task Force. The topic was chosen due to emerging evidence and increasing regulatory requirements to consider patient needs and capabilities in drug product development. It is well acknowledged that acceptability of a drug product and its dosage form is a fundamental aspect of patient centric drug product design which can directly impact adherence and intended use, hence effectiveness and safety. Despite the requirement to proof acceptability within the drug development program, respective methods to determine and compare the degree of acceptability of different dosage forms and drug product designs are still limited.

Evaluation of wave configurations in corrugated boards by experimental analysis (EA) and finite element modeling (FEM): the role of the micro-wave in packaging design.

The aim of this paper is to study the mechanical behavior of corrugated board boxes, focusing attention on the strength that the boxes are able to offer in compression under stacking conditions. A preliminary design of the corrugated cardboard structures starting from the definition of each individual layer, namely the outer liners and the innermost flute, was carried out. For this purpose, three distinct types of corrugated board structures that include flutes with different characteristics, namely the high wave (C), the medium wave (B), and even the micro-wave (E), were comparatively evaluated. More specifically, the comparison is able to show the potential of the micro-wave which would eventually allow a significant saving of cellulose in the fabrication process of the boxes, thus reducing the manufacturing costs and causing a lower environmental footprint. First, experimental tests were carried out to determine the mechanical properties of the different layers of the corrugated board structures. Tensile tests were performed on samples extracted from the paper reels used as base material for the manufacturing of the liners and flutes. Instead, the edge crush test (ECT) and box compression test (BCT) were directly performed on the corrugated cardboard structures. Secondly, a parametric finite element (FE) model to allow, on a comparative basis, the study of the mechanical response of the three different types of corrugated cardboard structures was developed. Lastly, a comparison between the available experimental results and the outputs of the FE model was carried out, with the same model being also adapted to evaluate additional structures where the E micro-wave was usefully combined with the B or C wave in a double-wave configuration.

Patient-Centric Design of Topical Dermatological Medicines.

Topical treatments are essential approaches to skin diseases but are associated with poor adherence. Topical vehicles have the primary purpose of ensuring drug effectiveness (by modulating drug stability and delivery, as well as skin properties) but have a marked impact on treatment outcomes as they influence patient satisfaction and, consequently, adherence to topical treatments. There is also a wide variety of vehicles available for topical formulations, which can complicate the decisions of clinicians regarding the most appropriate treatments for specific skin disorders. One of the possible strategies to improve topical-treatment adherence is the implementation of patient-centric drug-product design. In this process, the patient's needs (e.g., those related to motor impairment), the needs associated with the disease (according to the skin lesions' characteristics), and the patient's preferences are taken into consideration and translated into a target product profile (TPP). Herein, an overview of topical vehicles and their properties is presented, along with a discussion of the patient-centric design of topical dermatological medicines and the proposal of TPPs for some of the most common skin diseases.

Visual-Tactile Perception of Biobased Composites.

Biobased composites offer unique properties in the context of sustainable material production as well as end-of-life disposal, which places them as viable alternatives to fossil-fuel-based materials. However, the large-scale application of these materials in product design is hindered by their perceptual handicaps and understanding the mechanism of biobased composite perception, and its constituents could pave the way to creating commercially successful biobased composites. This study examines the role of bimodal (visual and tactile) sensory evaluation in the formation of biobased composite perception through the Semantic Differential method. It is observed that the biobased composites could be grouped into different clusters based on the dominance and interplay of various senses in perception forming. Attributes such as Natural, Beautiful, and Valuable are seen to correlate with each other positively and are influenced by both visual and tactile characteristics of the biobased composites. Attributes such as Complex, Interesting, and Unusual are also positively correlated but dominated by visual stimuli. The perceptual relationships and components of beauty, naturality, and value and their constituent attributes are identified, along with the visual and tactile characteristics that influence these assessments. Material design leveraging these biobased composite characteristics could lead to the creation of sustainable materials that would be more attractive to designers and consumers.

Identifying the Needs of Older Adults Associated with Daily Activities: A Qualitative Study.

INTRODUCTION: By 2050, older adults will constitute 16% of the world population; hence, there is an urgent demand and challenge to design solutions (products and services) that meet the needs of this age group. This study sought to analyse the needs that impact the well-being of Chilean older adults and present possible solutions through the design of products. METHODOLOGY: A qualitative study was used, where focus groups were held with older adults, industrial designers, health professionals, and entrepreneurs on the needs and design of solutions for older adults. RESULTS: A general map was obtained that linked the categories and subcategories related to the relevant needs and solutions, which were then classified in a framework. CONCLUSIONS: The resulting proposal places the needs in different fields of expertise; and thus, enables positioning, broadening, and expanding upon the map to share knowledge, between the user and key experts, to co-create solutions.